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Adenosine-anchored triphosphate subsite probing: distinguishing between HER-2 and HER-4 tyrosine protein kinases.

PMID: 14505676 (view PubMed database entry)
DOI: 10.1016/s0960-894x(03)00761-3 (read at publisher's website )

Fei Liu, Eric F Johnson, David J Austin, Karen S Anderson,

A strategy of full-site occupancy and stereospecific recognition in the triphosphate subsite was used to specifically inhibit two protein kinases HER-2 and HER-4 from the EGFR family. The SAR profiles of a panel of adenosine-anchored bicyclic heterocycles against HER-2 and HER-4 indicated that specificity can be derived for highly homologous protein kinases from stereospecific recognition in the triphosphate-subsite.

Bioorg. Med. Chem. Lett. (Bioorganic & Medicinal Chemistry Letters)
[2003, 13(20):3587-3592]

Cited: 4 times

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