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Exact breakpoints of the In(1)w m4 rearrangement.

PMID: 35903781 (view PubMed database entry)
DOI: 10.17912/micropub.biology.000608 (read at publisher's website )
PMCID: PMC9315410 (free full text version available)

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Alexander Solodovnikov, Sergey Lavrov,

<i>In(1)w <sup>m4</sup></i> has been known for decades as a classic example of a position effect variegation-causing rearrangement and has been mentioned in hundreds of publications. Nevertheless, its euchromatic breakpoint has not been localized with base-pair resolution. We performed nanopore sequencing of DNA from <i>In(1)w <sup>m4</sup></i> homozygous flies and determined the exact position of euchromatic (chrX:2767875) and heterochromatic breakpoints of the rearrangement. The heterochromatic breakpoint is located in an unlinked part of the genome in the region, enriched in TEs (transposable elements) fragments. A set of unique piRNAs could be detected in the region.

MicroPubl Biol (microPublication biology)
[2022, 2022:]

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