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1,2,4-Triazole-based anticonvulsant agents with additional ROS scavenging activity are effective in a model of pharmacoresistant epilepsy.

Barbara Kaproń, Robert Czarnomysy, Mariusz Wysokiński, Rudolf Andrys, Kamil Musilek, Andrea Angeli, Claudiu T Supuran, Tomasz Plech,

There are numerous studies supporting the contribution of oxidative stress to the pathogenesis of epilepsy. Prolonged oxidative stress is associated with the overexpression of ATP-binding cassette transporters, which results in antiepileptic drugs resistance. During our studies, three 1,2,4-triazole-3-thione derivatives were evaluated for the antioxidant activity and anticonvulsant effect in the ... Read more >>

J Enzyme Inhib Med Chem (Journal of enzyme inhibition and medicinal chemistry)
[2020, 35(1):993-1002]

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Predictors of outcome in childhood Plasmodium falciparum malaria.

Harsita Patel, Claire Dunican, Aubrey J Cunnington,

Plasmodium falciparum malaria is classified as either uncomplicated or severe, determining clinical management and providing a framework for understanding pathogenesis. Severe malaria in children is defined by the presence of one or more features associated with adverse outcome, but there is wide variation in the predictive value of these features. ... Read more >>

Virulence (Virulence)
[2020, 11(1):199-221]

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Social isolation and exclusion: the parents' experience of caring for children with rare neurodevelopmental disorders.

Genevieve Currie, Joanna Szabo,

Purpose: The experiences of parents caring for the complex care needs of children with rare neurodevelopmental disorders are not well understood. Parents struggle to meet their children's medical, behavioural, and social needs within and across health, social, and family systems. The purpose of this study was to explore the parents' ... Read more >>

Int J Qual Stud Health Well-being (International journal of qualitative studies on health and well-being)
[2020, 15(1):1725362]

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Beneficial effects of AAV1-Rheb(S16H) administration in the adult hippocampus.

Sang Ryong Kim,

Neural Regen Res (Neural regeneration research)
[2020, 15(8):1479-1480]

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Astrocytic modulation of potassium under seizures.

Fushun Wang, Xiaoming Qi, Jun Zhang, Jason H Huang,

The contribution of an impaired astrocytic K+ regulation system to epileptic neuronal hyperexcitability has been increasingly recognized in the last decade. A defective K+ regulation leads to an elevated extracellular K+ concentration ([K+]o). When [K+]o reaches peaks of 10-12 mM, it is strongly associated with seizure initiation during hypersynchronous neuronal ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(6):980-987]

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Electroencephalogram studies of hypoxic ischemia in fetal and neonatal animal models.

Hamid Abbasi, Charles P Unsworth,

Alongside clinical achievements, experiments conducted on animal models (including primate or non-primate) have been effective in the understanding of various pathophysiological aspects of perinatal hypoxic/ischemic encephalopathy (HIE). Due to the reasonably fair degree of flexibility with experiments, most of the research around HIE in the literature has been largely concerned ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):828-837]

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Optimal concentration of necrostatin-1 for protecting against hippocampal neuronal damage in mice with status epilepticus.

Dong-Qi Lin, Xin-Ying Cai, Chun-Hua Wang, Bin Yang, Ri-Sheng Liang,

Hippocampal neurons undergo various forms of cell death after status epilepticus. Necrostatin-1 specifically inhibits necroptosis mediated by receptor interacting protein kinase 1 (RIP1) and RIP3 receptors. However, there are no reports of necroptosis in mouse models of status epilepticus. Therefore, in this study, we investigated the effects of necrostatin-1 on ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):936-943]

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Neonatal Hypocalcemic Seizures in Offspring of a Mother With Familial Hypocalciuric Hypercalcemia Type 1 (FHH1).

Poonam Dharmaraj, Caroline M Gorvin, Astha Soni, Nick D Nelhans, Mie K Olesen, Hannah Boon, Treena Cranston, Rajesh V Thakker, Fadil M Hannan,

CONTEXT:Familial hypocalciuric hypercalcemia type 1 (FHH1) is caused by loss-of-function mutations of the calcium-sensing receptor (CaSR) and is considered a benign condition associated with mild-to-moderate hypercalcemia. However, the children of parents with FHH1 can develop a variety of disorders of calcium homeostasis in infancy. OBJECTIVE:The objective of this work is ... Read more >>

J. Clin. Endocrinol. Metab. (The Journal of clinical endocrinology and metabolism)
[2020, 105(5):]

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Neuronal and peripheral damages induced by synthetic psychoactive substances: an update of recent findings from human and animal studies.

Giulia Costa, Maria Antonietta De Luca, Gessica Piras, Jacopo Marongiu, Liana Fattore, Nicola Simola,

Preclinical and clinical studies indicate that synthetic psychoactive substances, in addition to having abuse potential, may elicit toxic effects of varying severity at the peripheral and central levels. Nowadays, toxicity induced by synthetic psychoactive substances poses a serious harm for health, since recreational use of these substances is on the ... Read more >>

Neural Regen Res (Neural regeneration research)
[2020, 15(5):802-816]

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EEG for children with complex febrile seizures.

Pankaj B Shah, Saji James, Sivaprakasam Elayaraja,

BACKGROUND:Febrile seizures can be classified as simple or complex. Complex febrile seizures are associated with fever that lasts longer than 15 minutes, occur more than once within 24 hours, and are confined to one side of the child's body. It is common in some countries for doctors to recommend an ... Read more >>

Cochrane Database Syst Rev (The Cochrane Database of Systematic Reviews)
[2020, 4:CD009196]

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Seizures following surgery for supratentorial extratemporal low-grade tumors in children: a multicenter retrospective study.

Jonathan Roth, Or Bercovich, Ashton Roach, Francesco T Mangano, Arvind C Mohan, Guillermo Aldave, Howard L Weiner, Ulrich-Wilhelm Thomale, Andreas Schaumann, Shimrit Uliel-Sibony, Shlomi Constantini,

OBJECTIVE:Resection of brain tumors may lead to new-onset seizures but may also reduce seizure rates in patients presenting with seizures. Seizures are seen at presentation in about 24% of patients with brain tumors. For lesional epilepsy in general, early resection is associated with improved seizure control. However, the literature is ... Read more >>

J Neurosurg Pediatr (Journal of neurosurgery. Pediatrics)
[2020, :1-7]

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Characterization of Pediatric Seizures in the Commonwealth of the Northern Mariana Islands.

Ahana Yogesh, Michael Taylor, And Mary P Chang,

Saipan is a United States (US) territory Western Pacific island where little recent data exists regarding epidemiology, clinical presentation, and standard of care for pediatric seizures. This paper characterizes these features in Saipan's pediatric population with comparisons to mainland US. This is a retrospective chart review of all pediatric patients ... Read more >>

Children (Basel) (Children (Basel, Switzerland))
[2020, 7(4):]

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Prognostic factors for short-term survival of dogs that experience postattenuation seizures after surgical correction of single congenital extrahepatic portosystemic shunts: 93 cases (2005-2018).

Ronan A Mullins, Carlos Sanchez Villamil, Laura E Selmic, Michael S Tivers, J Brad Case, Ameet Singh, Kelley M Thieman Mankin, Davina M Anderson, Robert N White, Kathryn M Pratschke, Hilde de Rooster, Anne Kummeling, Donald A Yool, Melanie Olive, Jean-Philippe Billet Dr Vét, Ines Gordo, Herve Brissot, Cameron Broome, Barbara M Kirby,

OBJECTIVE:To identify prognostic factors for short-term survival of dogs that experience seizures within 7 days after surgical correction of single congenital extrahepatic portosystemic shunts (cEHPSS). STUDY DESIGN:Multi-institutional retrospective study. SAMPLE POPULATION:Ninety-three client-owned dogs. METHODS:Medical records at 14 veterinary institutions were reviewed to identify dogs that underwent surgical attenuation of a single ... Read more >>

Vet Surg (Veterinary surgery : VS)
[2020, :]

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Prevention of sudden unexpected death in epilepsy: current status and future perspectives.

Max Christian Pensel, Robert Daniel Nass, Erik Taubøll, Dag Aurlien, Rainer Surges,

INTRODUCTION:Sudden unexpected death in epilepsy (SUDEP) affects about 1 in 1000 people with epilepsy, and even more in medically refractory epilepsy. As most people are between 20 and 40 years when dying suddenly, SUDEP leads to a considerable loss of potential life years. The most important risk factors are nocturnal ... Read more >>

Expert Rev Neurother (Expert review of neurotherapeutics)
[2020, :]

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High Rate of Febrile Seizures in Japanese Children With Occult Bacteremia.

Satoshi Kamidani, Kensuke Shoji, Eiki Ogawa, Takanori Funaki, Hiroki Mishina, Isao Miyairi,

OBJECTIVES:Fever of 39°C or higher and a white blood cell (WBC) count of 15,000/μL or greater are known predictors of occult bacteremia (OB). However, because of a decreasing prevalence of OB, WBC counts have become poor predictors of OB in populations of routinely immunized children. Thus, we aim to evaluate ... Read more >>

Pediatr Emerg Care (Pediatric emergency care)
[2020, 36(4):e199-e203]

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Altered integrity of corpus callosum in generalized epilepsy in relation to seizure lateralization after corpus callosotomy.

Po Ching Chen, Steven A Messina, Eduardo Castillo, James Baumgartner, Joo Hee Seo, Holly Skinner, Elakkat D Gireesh, Ki Hyeong Lee,

OBJECTIVE:Generalized-onset seizures are usually conceptualized as engaging bilaterally distributed networks with no clear focus. However, the authors previously reported a case series demonstrating that in some patients with generalized-onset seizures, focal seizure onset could be discovered after corpus callosotomy. The corpus callosum is considered to be a major pathway for ... Read more >>

Neurosurg Focus (Neurosurgical focus)
[2020, 48(4):E15]

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A knock-in mouse model for KCNQ2-related epileptic encephalopathy displays spontaneous generalized seizures and cognitive impairment.

Mathieu Milh, Pierre Roubertoux, Najoua Biba, Julie Chavany, Adeline Spiga Ghata, Camille Fulachier, Stephan Christopher Collins, Christel Wagner, Jean-Christophe Roux, Binnaz Yalcin, Marie-Solenne Félix, Florence Molinari, Pierre-Pascal Lenck-Santini, Laurent Villard,

OBJECTIVE:Early onset epileptic encephalopathy with suppression-burst is one of the most severe epilepsy phenotypes in human patients. A significant proportion of cases have a genetic origin, and the most frequently mutated gene is KCNQ2, encoding Kv7.2, a voltage-dependent potassium channel subunit, leading to so-called KCNQ2-related epileptic encephalopathy (KCNQ2-REE). To study ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Identification of a Novel MYH9 Mutation in a Young Adult With Inherited Thrombocytopenia and Recurrent Seizures by Targeted Exome Sequencing.

Eu Jeen Yang, Kyung Mi Park, Yoo-Mi Kim, Ki Sun Jung, Young Tak Lim, Chong Kun Cheon,

May-Hegglin anomaly (MHA) is a rare autosomal dominant disorder caused by a mutation in the myosin heavy chain 9 (MYH9) gene. MHA patients have variable clinical manifestations including thrombocytopenia, renal injury, hearing impairment, and cataracts. We describe a 25-year-old man with isolated thrombocytopenia initially. He experienced recurrent seizures with stable ... Read more >>

J. Pediatr. Hematol. Oncol. (Journal of pediatric hematology/oncology)
[2020, 42(3):e188-e192]

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Pathogenesis of peritumoral hyperexcitability in an immunocompetent CRISPR-based glioblastoma model.

Asante Hatcher, Kwanha Yu, Jochen Meyer, Isamu Aiba, Benjamin Deneen, Jeffrey L Noebels,

Seizures often herald the clinical appearance of gliomas or appear at later stages. Dissecting their precise evolution and cellular pathogenesis in brain malignancies could inform the development of staged therapies for these highly pharmaco-resistant epilepsies. Studies in immunodeficient xenograft models have identified local interneuron loss and excess glial glutamate release ... Read more >>

J. Clin. Invest. (The Journal of clinical investigation)
[2020, :]

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The Humanistic and Economic Burden of Pediatric Focal Seizures in the United States.

Sarah N Gibbs, Jiyoon Choi, Ibrahim Khilfeh, K Hamzah Ahmed, Irina Yermilov, Eric Segal,

OBJECTIVE:To better understand the humanistic and economic burden of focal seizures in children 2-12 years old. METHODS:We conducted a targeted literature review by searching MEDLINE for English-language publications reporting on children 2-12 years old with focal seizures published in the United States since 2008. RESULTS:Thirty-five publications were included. Incidence of ... Read more >>

J. Child Neurol. (Journal of child neurology)
[2020, :883073820911785]

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Epilepsy in LAMA2-related muscular dystrophy: An electro-clinico-radiological characterization.

Daniel Natera-de Benito, Jordi Muchart, Debora Itzep, Carlos Ortez, Lidia González-Quereda, Pía Gallano, Alia Ramirez, Javier Aparicio, Jana Domínguez-Carral, Laura Carrera-García, Jessica Expósito-Escudero, Nathalia Pardo Cardozo, Daniel Cuadras, Anna Codina, Cristina Jou, Cecilia Jimenez-Mallebrera, Francesc Palau, Jaume Colomer, Alexis Arzimanoglou, Andrés Nascimento, Victoria San Antonio-Arce,

OBJECTIVE:To delineate the epileptic phenotype of LAMA2-related muscular dystrophy (MD) and correlate it with the neuroradiological and muscle biopsy findings, as well as the functional motor phenotype. METHODS:Clinical, electrophysiological, neuroradiological, and histopathological data of 25 patients with diagnosis of LAMA2-related MD were analyzed. RESULTS:Epilepsy occurred in 36% of patients with ... Read more >>

Epilepsia (Epilepsia)
[2020, :]

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Prophylactic anticonvulsant therapy in high-grade glioma: A systematic review and meta-analysis of longitudinal studies.

Pedro David Delgado-López, Javier Martín-Alonso,

INTRODUCTION:It is common practice to prescribe prophylactic antiepileptic drugs (AED) to high-grade glioma (HGG) patients without a history of seizures, yet with limited evidence supporting its use. Ideally, the effectiveness of prophylactic anticonvulsants must outweigh the occurrence of adverse effects and interactions related to AED. The authors conducted a systematic ... Read more >>

Neurocirugia (Astur) (Neurocirugia (Asturias, Spain))
[2020, :]

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A Simple Technique for Endoscopic Hypothalamic Hamartoma Disconnection in Refractory Epilepsy: 2-Dimensional Operative Video.

Marcelo Budke, María Ángeles Pérez-Jiménez, José Hinojosa Mena-Bernal,

Hypothalamic hamartomas often cause refractory epilepsy, best controlled with surgery. A transcallosal interforniceal approach provides good outcomes although it has resulted in some complications including fornix lesions with transitory and permanent memory losses.1-2 Endoscopic disconnection is less invasive, avoids interhemispheric approach, callosotomy and fornix as well as propagation of epileptic ... Read more >>

Oper Neurosurg (Hagerstown) (Operative neurosurgery (Hagerstown, Md.))
[2020, :]

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Factors Associated With Seizure Onset in Children With Autism Spectrum Disorder.

Jamie K Capal, Eric A Macklin, Frances Lu, Gregory Barnes,

BACKGROUND AND OBJECTIVES:Children with autism spectrum disorder (ASD) have a higher prevalence of epilepsy compared with general populations. In this pilot study, we prospectively identified baseline risk factors for the development of seizures in individuals with ASD and also identified characteristics sensitive to seizure onset up to 6 years after ... Read more >>

Pediatrics (Pediatrics)
[2020, 145(Suppl 1):S117-S125]

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Effects of physiological parameter evolution on the dynamics of tonic-clonic seizures.

F Deeba, P Sanz-Leon, P A Robinson,

The temporal and spectral characteristics of tonic-clonic seizures are investigated using a neural field model of the corticothalamic system in the presence of a temporally varying connection strength between the cerebral cortex and thalamus. Increasing connection strength drives the system into ∼ 10 Hz seizure oscillations once a threshold is ... Read more >>

PLoS ONE (PloS one)
[2020, 15(4):e0230510]

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